Abstract
Specific immunosuppression, caused by the passive transfer of immune sera, and non-specific immunosuppression, caused by ACTH, were investigated for possible interactions. The data confirm earlier studies which show that both types of suppression when administered independently cause reductions in humoral immune responsiveness. However, when both suppressive methods were administered simultaneously a level of suppression occurred which was not greater than that caused by either method alone. Additionally, when ACTH-induced non-specific immunosuppression was established in donors, passive transfers of sera from these donors did not cause suppression in the recipients.
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