Year-end Sale % OFF 
Abstract
Specific and non-specific mechanisms of tumor growth facilitation were studied using methylcholanthrene (MCA)-induced fibrosarcomas in C3H/HeJ mice. In early and late stages of tumor growth, mice possessed non-specific, tumor-facilitating cells detected by local adoptive transfer assay (LATA). These cells appeared to be macrophages; they were radioresistant (700 rads), phagocytic, and adherent to plastic. Specific tumor facilitation was induced by treatment either with crude 3M KCl extracts, or with an acidic pIEF fraction (pI 3.5). After treatment with this material, animals displayed facilitated outgrowth of only MCA-F, but not the antigenically distinct MCA-D or MCA-C tumors. Thus in addition to non-specific stimuli, which accelerate neoplastic growth, tumors bear tumor-specific transplantation antigens (TSTA), which induce specific facilitation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
