Abstract
In the conscious normotensive rat, intracisternal neuropeptide Y (NPY) (1.25 nmol i.c.) gave rise to alterations in peripheral haemodynamic variables and glucose use within discrete areas of the CNS as measured by [ 14C]2-deoxyglucose aut autoradiography. The haemodynamic response to i.c. NPY comprised a transient hypertension followed by a prolonged hyptension and bradycardia. These cardiovascular responses to NPY were accompanied by a significant reduction in functton related glucose use in the area postrema (–29% from vehicle-injected controls), nucleus tractus solitarius (caudal portion –24%, rostral portion –19%), Kolliker-Fuse nucleus (–14%), inferior colliculus (–18%) and subfornical organ (–19%). It is proposed that the area postrema, nucleus tractus solitarius and Kolliker-Fuse nucleus in the brainstem are involved functionally in the haemodynamic response to i.c. NPY.
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