Abstract
The binding affinity of derivatives of the triphenylethylene (TPE) antioestrogen tamoxifen and of steroidal compounds for human liver antioestrogen binding sites (AEBS) was compared with their binding affinity for rat liver AEBS. Despite the observation of some quantitative differences overall a highly significant correlation between the relative binding affinity (RBA) for human and rat liver AEBS was found for all compounds tested ( r = 0.93, N = 19, P < 0.001). This was more pronounced for TPE derivatives ( r = 0.83, N = 12, P < 0.01) than for cholesterol derived compounds ( r = 0.64, N = 7, not significant). We conclude that AEBS from rat can be used instead fo huma livers as a model to study the interactions of antioestrogens with AEBS.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
