Abstract
The capacity of trinitrophenyl (TNP)-derivatized cells from syngeneic, allogeneic, and xenogeneic animals to induce contact sensitivity (CS) responses was studied in mice. The animals were immunized subcutaneously with TNP-cells and 5 days later CS responses were elicited in the ear by picryl chloride painting. Species-restricted phenomena were observed in this system as assessed in BALB/c recipients. The immunogenicity of xenogeneic TNP-cells of phylogenically remote origins such as chicken, guinea pig, and rabbit was negligible or very weak, whereas rat TNP-cells were moderately immunogenic. For syngeneic and allogeneic TNP-cells, absolute H-2 restriction was not apparent although syngeneic TNP-cells were the most immunogenic and the absence of syngeneic H-2-coded products led to a weakened induction. From these results, it was concluded that in TNP-cell-induced CS responses T-cells recognize TNP in association with some antigen possibly encoded by the MHC shared with mouse strains but not with other animals except the rat.
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