Abstract
Species distribution and antifungal susceptibility of Candida bloodstream isolates. 173 Candida species recovered from fungemic patients admitted to the largest tertiary-care military hospital between 2001 and 2006 in Ankara, Turkey evaluated retrospectively. Antifungal susceptibility of 95 isolates (45 Candida parapsilosis, 35 C. albicans, 7 C. tropicalis, 4 C. krusei, 3 C. glabrata, and 1 C. kefyr) was determined against fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and amphotericin B. C. albicans was the most common yeast (48.0%), followed by C. parapsilosis. Almost all strains showed low minimal inhibitory concentration (MIC) values to all six antifungals tested. Only 2 of 45 C. parapsilosis isolates were resistant to fluconazole, one was susceptible in a dose-dependent manner (SDD) to itraconazole, and 14 were nonsusceptible to caspofungin. Increasing prevalence of C. parapsilosis emphasizes a need for better catheter care and continuous surveillance programs.
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