Species distribution and drug-resistance analysis of urinary fungal infections in older adults

Abstract

Objective To analyze the detection rates, species distribution and drug-resistance of urinary fungal infection in elderly patients at Beijing Hospital from 2011 to 2013, in order to provide the basis for the reasonable clinical use of anti-epiphyte medicines. Methods Totally 263 patients with an average of 79.6 years old were collected from Beijing Hospital. The urine from freshly voided midstream or bladder puncture was collected under aseptic condition for fungal culture, then the strains of epiphytes were identified by using API 20C AUX. The drug sensitivity was tested with ATB fungus3. Results 263 strains of epiphytes were isolated from the 2 983 urine samples, of which 92 were C. tropicalis, 85 were C. glabrata, 77 were Candida albican, and 9 were other fungus candida. The rates of drug resistance to fluconazole were 14.1%(13 strains), 37.6%(32 strains) and 15.6%(12 strains), and to itraconazole were 16.3%(15 strains), 35.3%(30 strains) and 9.1%(7 strains), respectively. All of the 263 strains were not found to have drug resistance to amphotericin. Conclusions The isolation rate of urinary fungal infections is 8.8% in Beijing Hospital. The majority of the tested fungal are C. glabrata, C. tropicalis and Candida albican, the former has higher resistance rate to azoles, and the two latter have better sensitivity to azole, and all of them have the sensitivity to amphotericin. Key words: Fungus; Species distribution; Drug-resistance; Urinary system