Abstract
Abstract 1. 1. Suspensions of hepatocytes were prepared under the same conditions by in situ perfusion of rat or chicken livers with an enzyme solution for comparative metabolic studies. 2. 2. Isolated cells from either species incorporated 14 C-acetate into cellular lipids, but the rate of lipogenesis was more rapid in chicken hepatocytes. 3. 3. Dibutyryl cyclic AMP (0·1 mM) inhibited lipid synthesis in hepatocytes from either species, but its effect was far greater in chicken hepatocytes. Cyclic AMP (0·1 mM) had no effect on lipogenesis in rat hepatocytes while its effect on this process in chicken hepatocytes was similar to that of the dibutyryl derivative. 4. 4. Epinephrine and glucagon were antilipogenic in cells from both species, but each hormone had a more potent inhibitory effect in chicken hepatocytes. In each species, the effect of glucagon was greater than that of epinephrine.
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