Abstract
Marked differences in amphetamine toxicity between rats and mice are presented. The major differences can be summarized as follows: 1. 1. The effect of aggregation on amphetamine toxicity, while prominent in mice, is not a factor in rats. 2. 2. The protective effect of a single dose of reserpine has been confirmed in grouped mice. The rat, however, shows an increased susceptibility to some doses of amphetamine under these conditions. 3. 3. A dramatic increase in the lethality of amphetamine is produced in rats chronically treated with reserpine. This effect is equivocal in mice.
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