Abstract
Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong preference to use the orthologous region (allelic gene conversion), which causes non-Mendelian allelic distortion, but paralogous or duplicated regions can also be used for the repair (inter-locus gene conversion, also referred to as non-allelic and ectopic gene conversion). The focus of this special issue is the latter, interlocus gene conversion; the rate is lower than allelic gene conversion but it has more impact on phenotype because more drastic changes in DNA sequence are involved. [...].
Highlights
Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment
This special issue consists of 10 review papers covering various aspects of interlocus gene conversion
Gene conversion occurs in mitosis; the mechanisms should be the same but different proteins may be involved
Summary
Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. This special issue consists of 10 review papers covering various aspects of interlocus gene conversion. Hastings [1] provides a review on the basic mechanisms of gene conversion in meiotic cells.
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