Abstract
The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.
Highlights
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The articles in the present issue cover a range of topics including the use extracellular matrix (ECM) components to manufacture biologic scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair
The article highlights the diversity of decellularized scaffolds that are in clinical use, showing that it is not necessary to use a tissue-specific scaffold material to promote constructive tissue remodeling and that scaffold materials derived from intestine, bladder or amniotic membrane are practical for promoting skin wound repair
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The focus of this Special Issue is on scaffolds and the use extracellular matrix (ECM) and its components in the development of biologic scaffolds. The articles in the present issue cover a range of topics including the use ECM components to manufacture biologic scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair.
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