Abstract
Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca 2+ stores. The Golgi apparatus has Ca 2+-release channels and a Ca 2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca 2+-ATPases (SERCA) and secretory-pathway Ca 2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca 2+ and Mn 2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca 2+ and Mn 2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 ( ATP2C1) gene causes Hailey–Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
