Abstract
Background: Understanding the spatiotemporal trends of colorectal cancer (CRC) deaths caused by low physical activity (LPA) and high body mass index (BMI) is essential for the prevention and control of CRC. We assessed patterns of LPA and high BMI-induced CRC deaths from 1990 to 2019 at global, regional, and national levels.Methods: Data on CRC deaths due to LPA and high BMI was downloaded from the Global Burden of Disease 2019 Study. We calculated estimated annual percentage change (EAPC) to quantify spatiotemporal trends in the CRC age-standardized mortality rate (ASMR) due to LPA and high BMI.Results: In 2019, CRC deaths due to LPA and high BMI were estimated as 58.66 thousand and 85.88 thousand, and the corresponding ASMRs were 0.77/100,000 and 1.07/100,000, with EAPCs of−0.39 [95% confidence interval (CI):−0.49,−0.29] and 0.64[95% CI: 0.57, 0.71] from 1990 to 2019 respectively. Since 1990, the ASMR of CRC attributable to LPA and high BMI has been on the rise in many geographic regions, especially in low middle and middle sociodemographic index (SDI) regions. Thirteen countries had a significant downward trend in CRC ASMR attributed to LPA, with EAPCs < −1. And, only 4 countries had a significant downward trend in CRC ASMR attributable to high BMI, with EAPCs < −1. Countries with a higher baseline burden in 1990 and a higher SDI in 2019 had a faster decline in ASMR due to high BMI and LPA.Conclusions: The burden of CRC caused by LPA and high BMI is on the rise in many countries. Countries should adopt a series of measures to control the local prevalence of obesity and LPA in order to reduce disease burden, including CRC.
Highlights
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death from cancer in the world [1]
Understanding the geographic and temporal trends and its influencing factors of CRC disease burden caused by low physical activity (LPA) and high body mass index (BMI) will make the formulation of CRC prevention and control policies more targeted
The CRC deaths caused by LPA was higher in females than in males, the corresponding age-standardized mortality rate (ASMR) was higher in males than that in females, with ASMR of 0.73 (95% uncertainty interval (UI) 0.23–1.35) and 0.81 (95% UI 0.20–1.60) for females and males, respectively
Summary
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death from cancer in the world [1]. In 2019, The Global Burden of Disease (GBD) 2017 Colorectal Cancer Collaborators explored the incidence, mortality, and disability of CRC in 195 countries and territories around the world from 1990 to 2017, and the proportion of CRC disability-adjusted life years (DALYs) attributable to risk factors (smoking, drinking, LPA, high BMI, high fasting plasma glucose and dietary) in 2017, which provided a solid foundation for the prevention and control of CRC [14]. Understanding the geographic and temporal trends and its influencing factors of CRC disease burden caused by LPA and high BMI will make the formulation of CRC prevention and control policies more targeted. Understanding the spatiotemporal trends of colorectal cancer (CRC) deaths caused by low physical activity (LPA) and high body mass index (BMI) is essential for the prevention and control of CRC. We assessed patterns of LPA and high BMI-induced CRC deaths from 1990 to 2019 at global, regional, and national levels
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