Abstract
A multipotent cell population co-expressing the transcription factors Scleraxis (Scx) and SRY-box 9 (Sox9) has been shown to contribute to the formation of entheses during mouse embryonic development. Previously, fibrocartilaginous enthesis was demonstrated to form during the postnatal stage. However, whether Scx+/Sox9+ progenitors participate in the postnatal formation and maturation of the fibrocartilage layer is unclear. This study aimed to investigate the contribution of Scx+/Sox9+ progenitors to fibrocartilaginous enthesis formation by evaluating their spatiotemporal localization during the postnatal maturation of the supraspinatus tendon enthesis using ScxGFP transgenic mice.
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