Abstract
Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA–organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA–organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons.
Highlights
Messenger RNAs are distributed throughout subcellular compartments and subject to locally organized translation for the purpose of protein enrichment or sequestration
Recent studies have found a new mode of messenger RNA (mRNA) transport, localization, and translation in axons, where organelles such as endosomes and lysosomes are involved in these events
The authors showed that local translation occurred in close proximity to Rab7a-associated late endosomes and mitochondria, suggesting that membranous organelles may serve as sites for local translation for a significant fraction of axonal mRNAs (Figure 1A; reviewed in Béthune et al, 2019; Rossoll and Bassell, 2019)
Summary
Messenger RNAs (mRNAs) are distributed throughout subcellular compartments and subject to locally organized translation for the purpose of protein enrichment or sequestration. Recent studies have found a new mode of mRNA transport, localization, and translation in axons, where organelles such as endosomes and lysosomes are involved in these events.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
