Abstract
The advent of Förster Resonance Energy Transfer (FRET) biosensor transgenic animals presents the unique opportunity to spatially specify and quantify the level of active signal transduction within individual cells of a tissue with subcellular resolution. The type of information gleaned by these biosensors are key for understanding the dynamic role of signaling intermediates in regulating cellular plasticity during developmental and regenerative processes. The modified Raichu-Rac1 biosensors transgenically encoded in mice FRET when bound to GTP and report active signal transduction.
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