Spatiotemporal distribution of human brucellosis in Inner Mongolia, China, in 2010\u20132015, and influencing factors

Danyan Liang,Shiyuan Li,Yunpeng Li,Maolin Du,Ruiqi Wang,Mingming Xue,Shaohua Yin,Weidong Guo,Min Yang,Buyun Cui,Wenrui Wang,Jing Wu,Dan Liu,Xuemei Wang

doi:10.1038/s41598-021-03723-9

Abstract

Human brucellosis is caused by Brucella species and remains a major burden in both human and domesticated animal populations, especially in Inner Mongolia, China. The aims of this study were to analyze the spatiotemporal trends in human brucellosis in Inner Mongolia during 2010 to 2015, to explore the factors affecting the incidence of brucellosis. The results showed that the annual incidence was 29.68–77.67 per 100,000, and peaked from March to June. The majority of human brucellosis was male farmers and herdsmen, aged 40–59 years. The high-risk areas were mainly Xilin Gol League and Hulunbeier City. The incidence of human brucellosis in Inner Mongolia decreased during 2010 to 2015, although the middle and eastern regions were still high-risk areas. The regions with larger number of sheep and cattle, lower GDP per capita, less number of hospital beds, higher wind speed, lower mean temperature more likely to become high-risk areas of human brucellosis.

Highlights

Human brucellosis is caused by Brucella species and is a zoonotic infectious disease
The main purposes of this study were to describe the epidemiology of human brucellosis in Inner Mongolia during 2010–2015, to investigate the spatiotemporal pattern of human brucellosis and the association with risk factors of the disease
The temporal trend of brucellosis in Inner Mongolia fluctuated greatly, and the overall trend of the relative risk (RR) decreased from 1.134 in 2010 to 0.797 in 2015

Summary

Introduction

Human brucellosis is caused by Brucella species and is a zoonotic infectious disease. According to the World Health Organization, more than 500,000 new cases of human brucellosis occur globally each year. Human brucellosis is listed as one of the statutory notifiable infectious diseases by the World Organization for Animal H ealth[7]. Human brucellosis outbreaks have been reported in 28 areas of China, including Inner Mongolia, Jilin, and Heilongjiang[12]. Inner Mongolia is one of the most seriously affected regions in China and considered a focal area for study of human brucellosis. In 2005–2010, Inner Mongolia accounted for 33.2–68.3% of the country’s total human brucellosis b urden[12]. In 2011, 20,845 cases of human brucellosis were reported in Inner Mongolia[11], accounting for 45.8% of all cases in China in 201315. The main purposes of this study were to describe the epidemiology of human brucellosis in Inner Mongolia during 2010–2015, to investigate the spatiotemporal pattern of human brucellosis and the association with risk factors of the disease

Objectives

Methods

Results

Discussion

Conclusion