Abstract
IntroductionBreast cancer is a leading tumor with a high mortality in women. This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.MethodsThe data on breast cancer incidence were obtained from the Shenzhen Cancer Registry System. To describe the temporal trend, the average annual percentage change (AAPC) was analyzed using a joinpoint regression model. Spatial autocorrelation and a retrospective spatio-temporal scan approach were used to detect the spatio-temporal cluster distribution of breast cancer cases.ResultsBreast cancer ranked first among different types of cancer in women in Shenzhen between 2007 and 2012 with a crude incidence of 20.0/100,000 population. The age-standardized rate according to the world standard population was 21.1/100,000 in 2012, with an AAPC of 11.3%. The spatial autocorrelation analysis showed a spatial correlation characterized by the presence of a hotspot in south-central Shenzhen, which included the eastern part of Luohu District (Donghu and Liantang Streets) and Yantian District (Shatoujiao, Haishan, and Yantian Streets). Five spatio-temporal cluster areas were detected between 2010 and 2012, one of which was a Class 1 cluster located in southwestern Shenzhen in 2010, which included Yuehai, Nantou, Shahe, Shekou, and Nanshan Streets in Nanshan District with an incidence of 54.1/100,000 and a relative risk of 2.41; the other four were Class 2 clusters located in Yantian, Luohu, Futian, and Longhua Districts with a relative risk ranging from 1.70 to 3.25.ConclusionsThis study revealed the spatio-temporal cluster pattern for the incidence of female breast cancer in Shenzhen, which will be useful for a better allocation of health resources in Shenzhen.
Highlights
Breast cancer is a leading tumor with a high mortality in women
This study aimed to explore the spatio-temporal distribution pattern of female breast cancer using the cancer information obtained from the Shenzhen Cancer Registry System
The geographic distribution of the incidence of breast cancer was characterized by a higher incidence in urban areas than in rural areas, with the lowest incidence on Dalang Street (WASR: 4.1/100,000) in Longhua District and the highest incidence on Shatoujiao Street (WASR: 90.5/100,000) in Yantian District
Summary
Breast cancer is a leading tumor with a high mortality in women. This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012. Breast cancer is a leading tumor among women worldwide, with an incidence that has displayed a gradual increasing trend in many countries over the past 30 years [1]. According to the GLOBOCAN 2012 released by the International Agency of Research on Cancer (IARC), there were approximately 1.7 million newly diagnosed cases of breast cancer and 0.5 million deaths in women worldwide in 2012 [2]. In China, breast cancer ranked as the most common type of cancer and the fifth leading cause of cancer deaths. Studies are warranted to explore the causes of breast cancer in China
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