Abstract
An analysis of the practical implementation of the VOISINER method for achieving spatially localized NMR is presented. The VOISINER (volume of interest by selective inversion, excitation, and refocusing) field gradient and radiofrequency pulse sequence relies upon the use of frequency-selective pulses in the presence of pulsed field gradients to enable easy control of the position and the size of the selected volume. Furthermore, it can be combined with conventional spin-echo imaging to facilitate the selection of the region of interest and optimization of the spatial selectivity of the localization process. Its performance is examined under various experimental conditions in order to evaluate the factors that influence the efficiency of its spatial selectivity and detection sensitivity. Potential extensions of the VOISINER technique for extracting high-resolution NMR parameters have also been explored.
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