Abstract
The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO 2) and glucose use (CMR glc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO 2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO 2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO 2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO 2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO 2 while CMRO 2 rose when actual motion commenced.
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