Abstract
Early afterdepolarizations (EAD) can lead to lethal ventricular arrhythmias under pathological conditions. However, it remains unclear how EAD events at the cellular level are spatially organized to induce and maintain ventricular arrhythmias, and whether spatial-temporal patterns of EADs at the tissue level are associated with T wave abnormalities that are often observed in Long QT syndrome (LQTS), e.g. broad-based, notched or bifid, late appearance and pointed T waves. Here, a tissue model of the Purkinje-ventricular system (PVS) was developed to quantitatively investigate the spatial-temporal dynamics and patterns of EADs during T wave abnormalities.
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