Abstract
A microfluidic device based on a pair of slant-finger interdigital transducers (SFITs) is developed to achieve a selective and flexible manipulation of microbubbles (MBs) by surface acoustic waves (SAWs). The resonance frequency of SAWs generated by the SFITs depends on the location of its parallel pathway; the particles at different locations of the SAWs' pathway can be controlled selectively by choosing the frequency of the excitation signal applied on the SFITs. By adjusting the input signal continuously, MBs can be transported along the acoustic aperture precisely. The displacement of MBs has a linear relationship with the frequency shift. The resolution of transportation is 15.19 ± 2.65 μm when the shift of input signal frequency is at a step of 10 kHz. In addition, the MBs can be controlled in a two-dimensional plane by combining variations of the frequency and the relative phase of the excitation signal applied on the SFITs simultaneously. This technology may open up the possibility of selectively and flexibly manipulating MBs using a simple one-dimensional device.
Highlights
Cells,16,20–22 and organisms.23 The traveling surface acoustic waves (SAWs) with the low power consumption is developed to separate various particles in size through a Schr€oder diffuser.24 Guo et al have demonstrated that a controllable motive force generated by SAWs can be used to precisely control the intercellular distance.25 bioeffects on living tissues induced by SAWs can be readily investigated at cellular and molecular levels
A microfluidic device based on a pair of slant-finger interdigital transducers (SFITs) is developed to achieve a selective and flexible manipulation of microbubbles (MBs) by surface acoustic waves (SAWs)
The resonance frequency of SAWs generated by the SFITs depends on the location of its parallel pathway; the particles at different locations of the SAWs’ pathway can be controlled selectively by choosing the frequency of the excitation signal applied on the SFITs
Summary
Cells, and organisms. The traveling SAWs with the low power consumption is developed to separate various particles in size through a Schr€oder diffuser. Guo et al have demonstrated that a controllable motive force generated by SAWs can be used to precisely control the intercellular distance. bioeffects on living tissues induced by SAWs can be readily investigated at cellular and molecular levels.. With the development of the MBs, the molecular probes, such as tissue-specific drugs and genes, can be coupled to the shell of MBs, enabling the realization of ultrasound molecular imaging and targeted drug delivery.. All the MBs in the acoustic field perform the essentially same movement, and acoustic manipulation has emerged as a powerful tool for massively parallel manipulation of MBs and living cells. Flexible and dynamic manipulation in two dimensions can be performed in this microfluidic device by a combination of the phase-shift and frequency-shift methods
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