Abstract
Results: The 5-year actuarial local control, local-regional control, and cause-specific survival rates for patients with early-Stage (T1/T2) vs. late-Stage (T3) tumors were 74% vs. 55% (p = 0.27), 63% vs. 38% (p = 0.16), and 70% vs. 41% (p = 0.04), respectively. The overall local control, local-regional control, and cause-specific survival rates were 62%, 48%, and 54%, respectively. The regional control rate was 83% (p = 0.6) for both the clinical N0 and N1 groups. There were 12 local recurrences and 4 neck recurrences as the first site of failure with 1 successful surgical salvage. Five of 24 (21%) patients who underwent surgery had significant complications (Grade 3 or 4) while 2 of 30 (7%) patients who underwent RT had Grade 3 complications. Conclusions: This study represents one of the largest series specifically addressing outcomes following RT for squamous cell carcinoma of the EAC. Early-stage tumors achieved better local and local-regional control than late-stage tumors, which translated into a superior cause-specific survival. Less than half of the patients (13 of 30; 43%) were cured without significant complications, suggesting a suboptimal therapeutic ratio with our current approach to local management.
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