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Abstract
In our work, we investigate physicochemical and optical properties of double-strand DNA dispersions. The study of these properties is of biological interest, because it allows one to describe the characteristics of certain classes of chromosomes and DNA containing viruses. The package pattern of DNA molecules in the dispersions particles (DP) is examined. The consideration of the DNA liquid-crystalline DP optical activity based on the theory of electromagnetic wave absorption by large molecular aggregates has been performed. The investigation is also focused on various effects induced by the interaction between biological active compounds and DNA in the content of liquid-crystalline DP.
Highlights
The nature of ds DNA dispersions properties is interesting from at least two points of view
It is well known that the phase exclusion of the low molecular mass, rigid, linear, ds DNA is realized under intensive mixing of equal volumes the water-salt solutions containing poly(ethyleneglycol), PEG, with water-salt solutions containing a very low (510 μg ml-1) concentration of ds DNA at room temperature
The particles of the low molecular mass ds DNA dispersions are microscopic droplets of concentrated DNA solution, which cannot be taken in hand (The mode of the ds DNA packing in the LCD particles can model the packing of ds DNA in the primitive biological objects above)
Summary
The nature of ds DNA dispersions properties is interesting from at least two points of view. From the theoretical point of view, the interest is caused by the fact that the physicochemical properties of dispersion particles with size 100 - 1,000 Ǻ can significantly differ from typical continuous solid phases’ properties.
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