Spatial Navigation.

Abstract

The hippocampus is critical for spatial navigation. In this review, we focus on the role of the hippocampus in three basic strategies used for spatial navigation: path integration, stimulus-response association, and map-based navigation. First, the hippocampus is not required for path integration unless the path of path integration is too long and complex. The hippocampus provides mnemonic support when involved in the process of path integration. Second, the hippocampus's involvement in stimulus-response association is dependent on how the strategy is conducted. The hippocampus is not required for the habit form of stimulus-response association. Third, while the hippocampus is fully engaged in map-based navigation, the shared characteristics of place cells, grid cells, head direction cells, and other spatial encoding cells, which are detected in the hippocampus and associated areas, offer a possibility that there is a stand-alone allocentric space perception (or mental representation) of the environment outside and independent of the hippocampus, and the spatially specific firing patterns of these spatial encoding cells are the unfolding of the intermediate stages of the processing of this allocentric spatial information when conveyed into the hippocampus for information storage or retrieval. Furthermore, the presence of all the spatially specific firing patterns in the hippocampus and the related neural circuits during the path integration and map-based navigation support such a notion that in essence, path integration is the same allocentric space perception provided with only idiothetic inputs. Taken together, the hippocampus plays a general mnemonic role in spatial navigation.