Spatial interaction between tissue pressure and skeletal muscle perfusion during contraction

Abstract

The vascular waterfall theory attributes decreased muscle perfusion during contraction to increased intramuscular pressure ( P IM) and concomitant increase in venous resistance. Although P IM is distributed during contractions, this theory does not account for heterogeneity. This study hypothesises that pressure heterogeneity could affect the interaction between P IM rise and perfusion. Regional tissue perfusion during submaximum (100 kPa) tetanic contraction is studied, using a finite element model of perfused contracting skeletal muscle. Capillary flow in muscles with one proximal artery and vein (SIM 1) and with an additional distal artery and vein (SIM 2) is compared. Blood flow and pressures at rest and P IM during contraction (∼25 kPa maximally) are similar between simulations, but capillary flow and venous pressure differ. In SIM 2, venous pressure and capillary flow correspond to P IM distribution, whereas capillary flow in SIM 1 is less than 10% of flow in SIM 2, in the muscle half without draining vein. This difference is caused by a high central P IM, followed by central venous pressure rise, in agreement with the waterfall theory. The high central pressure (SIM 1), obstructs outflow from the distal veins. Distal venous pressure rises until central blood pressure is reached, although local P IM is low. Adding a distal vein (SIM 2) restores the perfusion. It is concluded that regional effects contribute to the interaction between P IM and perfusion during contraction. Unlike stated by the vascular waterfall theory, venous pressure may locally exceed P IM. Although this can be explained by the principles of this theory, the theory does not include this phenomenon as such.