Abstract
The feasibility of the spatial frequency domain imaging (SFDI) for early treatment assessment in a mouse femoral injury model was investigated. For mice with and without treatment, the revascularization process was monitored by SFDI, which provides the total hemoglobin concentration (THC) of the injured bone and surrounding soft tissues. The biomechanical strength of the healed femurs was measured after 4 weeks of healing. The correlation between the SFDI-derived THC and the biomechanical strength will be investigated. Such correlation will be used to develop a prediction model to estimate the bone healing outcome at an early time point.
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