Abstract
Contrary to previous beliefs, the brain has a potential to regenerate itself. Neurogenesis, i.e. the cell division of neuronal precursor cells in the adult brain, and their subsequent differentiation to neurons, has been observed particularly in two areas of the brain, the subgranular zone [SGZ] of the dentate gyrus and the subventricular zone [SVZ] 1. Neurogenesis appears to be stimulated by various noxious insults, e.g. ischemia, seizures, suggesting that it is part of an endogenous repair mechanism of the brain. However, stress, e.g. inflammation, radiation, can also disrupt neurogenesis 2, 3, and the overall significance of the phenomenon in relation to brain damage remains unclear. We investigated the differential effects of a well defined focal ischemic insult on neurogenesis in two remote germinal areas of murine brains.
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