SPATIAL AND MECHANOEMISSION CHAOS OF MECHANICALLY DEFORMED TUMOR CELLS

Abstract

The development and spreading of tumor process is accompanied by changes in nonlinear (chaotic) dynamics of mechanochemical interaction process in the group of cells. Taking into consideration spatial irregularity and heterogeneity of internal structures of tumor cells, we suggested that treatment by mechanically deformed (MD) syngeneic tumor cells (STC) would be accompanied by changed influence on malignant growth. The objective of this work was to compare spatial, mechanoemission (ME) chaos of MD STC of carcinoma Lewis and melanoma B16 and their malignant growth. MD STC preparation included the aseptic removal of the animal tumor, lyophilization and next mechanical deformation in the microvibratory mill. The suspension of non-deformed or MD STC was injected intraperitoneally. Morphological, morphometric and mechanoemission studies used for estimate of spatial chaos and heterogeneity structure in tumor cells and blood. For Lewis carcinoma the reduction of spatial and ME chaos of cells is accompanied by regression in tumor growth and metastasis. For melanoma B16 the decrease of spatial chaos and the increase of ME chaos in cells is accompanied by initiation of tumor growth and metastasis. These results illustrated equivalent tendencies in chaos changing in spatial and ME chaos for carcinoma Lewis, while opposite tendencies were observed for melanoma B16. Blood ME of mice with melanoma B16 have greater ME chaos in comparison with animals with Lewis carcinoma. This confirmed that the concept of deterministic chaos is hierarchical for the host during cancer process. Results of comparative analysis between spatial, mechanoemission chaos of MD STC and malignant growth could be useful for gain a better understanding relationship of nonlinear biomechanical processes to tumor cells.