Abstract
BackgroundOral cancer (OC) is among the ten most common cancers and the seventh most frequent cause of death worldwide. It has been reported that these incidence rates are higher in developed country and these mortality rates are higher in less developed areas. So, the objective of the present study was to analyze the spatial joint distribution and to explore possible associations of the epidemiological aspects with mortality rates due to OC in the Brazil.MethodsAn exploratory ecological study investigated the global spatial autocorrelation of epidemiological aspects with mortality rates due to OC from the Brazilian Federative Units (FUs) (n = 27) in the period 2005–2014, using the “global” and “local” Moran statistic method and a multiple spatial regression, having as variables of exposure the habits and lifestyle, sociodemographic indicators, the consumption of pesticides, the presence of comorbidities, the use of health services and food consumption; and, as a variable response, mortality rates due to OC. The software used was Stata 11.0, SPSS 18.0 and GeoDa 0.95-i.ResultsThe spatial distribution of OC mortality rates to age-standard was not random and showed high spatial autocorrelation and predominance of significant spatial groupings in the Central-South region of Brazil. In the multiple regression, statistically negative associations were observed between the Human Development Index (HDI) and OC age-standardized in the studied period (p < 0.05) and positive associations among the proportion of the population with dental appointment within last year, percentage of consumption of oils and fats, percentage of consumption of ready-to-eat foods and industrial mixtures and percentage of overweight adults with this type of cancer (p < 0.05).ConclusionThis is the first study that analyzed the factors associated to the spatial clusters of mortality due to oral cancer in the Brazilian FUs. A fairly unequal distribution of OC mortality rates was found, being that these rates presented inverse association with HDI and direct association with dental appointment, consumption of oils and fats, ready-to-eat foods and industrial mixtures consumption and overweight these rates. It suggests the need to redirect Brazilian public policies aimed at combating them so that they cease to be temporary and become permanent.
Highlights
Oral cancer (OC) is among the ten most common cancers and the seventh most frequent cause of death worldwide
The International Classification of Diseases for Oncology of possible sites for malignant neoplasms is accepted by World Health Organization and defines the sites belonging to OC with those involving the topographic regions of the lip, oral cavity and pharynx [3]
It is observed that the highest rates occurred in the South and Southeast region, followed by the Northeast and Midwest regions of Brazil, Fig. 1 Mortality rates for mouth cancer standardized for the age of 40 years or over per 100,000 inhabitants, in the Brazilian Federative Units, in the period from 2005 to 2014, according to tertile with the lowest rates being identified in the Northern region
Summary
Oral cancer (OC) is among the ten most common cancers and the seventh most frequent cause of death worldwide. The International Classification of Diseases for Oncology of possible sites for malignant neoplasms is accepted by World Health Organization and defines the sites belonging to OC with those involving the topographic regions of the lip, oral cavity and pharynx [3]. This pathology has its development stimulated by the interaction of environmental, behavioral and occupational factors (carcinogens or carcinogens) and factors related to the host itself (age, race, sex, spontaneous mutations and inherited mutations) [4]. There are other factors that may increase the risk of this malignant neoplasm, as well as exposure to pesticides, combustion gases, biomass burning, human papillomavirus (HPV) exposure and sun exposure [7, 8]
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