Abstract
Premature ejaculation is a disorder that affects many men. This pathology may be the result of uncoordinated contraction of the vas deferens. Ageratum conyzoides is a plant used for the treatment of several pathologies in many regions in Brazil. Both in vitro and in vivo studies have shown that the A. conyzoides has many pharmacological properties, including a beneficial effect on benign prostatic hyperplasia, antitumoral effect and relaxation of gastrointestinal and genitourinary organs. The aim of the present study was to evaluate the effect of the A. conyzoides essential oil in the contractility of the vas deferens. 60-day old male Swiss mice were used in the experiment. Vas deferens were stimulated with potassium chlroride (KCl 80 mM), which induced a biphasic contractile response (phasic and tonic). The treated group had previous growing doses of the essential oil. The A. conyzoides induced the relaxation both of the phasic and tonic components, although the effect on the tonic component was statistically significant when compared to phasic. This inhibitory effect of the contractility may be potentially explored in order to guide clinical studies to treat premature ejaculation.
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