Spaceflight-induced neuroplasticity in humans as measured by MRI: what do we know so far?

Angelique Van Ombergen,Steven Laureys,Stefan Sunaert,Floris L Wuyts,Paul M Parizel,Elena Tomilovskaya

doi:10.1038/s41526-016-0010-8

Abstract

Space travel poses an enormous challenge on the human body; microgravity, ionizing radiation, absence of circadian rhythm, confinement and isolation are just some of the features associated with it. Obviously, all of the latter can have an impact on human physiology and even induce detrimental changes. Some organ systems have been studied thoroughly under space conditions, however, not much is known on the functional and morphological effects of spaceflight on the human central nervous system. Previous studies have already shown that central nervous system changes occur during and after spaceflight in the form of neurovestibular problems, alterations in cognitive function and sensory perception, cephalic fluid shifts and psychological disturbances. However, little is known about the underlying neural substrates. In this review, we discuss the current limited knowledge on neuroplastic changes in the human central nervous system associated with spaceflight (actual or simulated) as measured by magnetic resonance imaging-based techniques. Furthermore, we discuss these findings as well as their future perspectives, since this can encourage future research into this delicate and intriguing aspect of spaceflight. Currently, the literature suffers from heterogeneous experimental set-ups and therefore, the lack of comparability of findings among studies. However, the cerebellum, cortical sensorimotor and somatosensory areas and vestibular-related pathways seem to be involved across different studies, suggesting that these brain regions are most affected by (simulated) spaceflight. Extending this knowledge is crucial, especially with the eye on long-duration interplanetary missions (e.g. Mars) and space tourism.

Highlights

More than 50 years of manned spaceflight have taught us that space is a hostile environment for human health; microgravity, ionizing radiation, absence of circadian rhythm, confinement and isolation are just some of the stressors space travelers encounter.[1,2] Obviously, all of the latter can have an impact on human physiology and lead to detrimental changes.[3]
When focussing on neuroplasticity measured by magnetic resonance imaging (MRI) only, we suggest transcranial magnetic stimulation (TMS) to become part of a countermeasure regime for can only assess the human brain before and after spaceflight
These changes reflect most likely an underlying neural component of the common detrimental changes observed in space travelers such as problems with sensorimotor control and motor coordination, space motion sickness and a hampered otolith and vestibulo-autonomic functioning

Summary

Introduction

More than 50 years of manned spaceflight have taught us that space is a hostile environment for human health; microgravity, ionizing radiation, absence of circadian rhythm, confinement and isolation are just some of the stressors space travelers encounter.[1,2] Obviously, all of the latter can have an impact on human physiology and lead to detrimental changes.[3].

Results

Conclusion