Soy Products Ameliorate Obesity-Related Anthropometric Indicators in Overweight or Obese Asian and Non-Menopausal Women: A Meta-Analysis of Randomized Controlled Trials.

Mu Mu,Wei Wei,Cui Cui,Lu Lu,Liu Liu,Kou Kou,Tian Tian,Wang Wang,Li Li,Zhang Zhang

doi:10.3390/nu11112790

Abstract

Background: The effect of soy products on the weight of overweight or obese people is controversial, so we aimed to conduct a systematic review and a meta-analysis of published randomized controlled trials to analyze whether supplementation with soy products can help them to lose weight. Methods: The relevant data before January 2019 in PubMed, Embase and Cochrane Library were searched. A random-effect model was adopted to calculate the weighted average difference of net changes of body weight, body mass index (BMI), body fat percentage, fat mass, waist circumference, etc. Results: A total of 22 trials (870 overweight or obese participants) were reflected in the present meta-analysis. Analysis showed that soy products significantly reduced body weight, BMI, body fat percent and waist circumference in overweight or obese Asian populations (−0.37 kg, P = 0.010; −0.27 kg/m2, P = 0.042; −0.36%, P = 0.032; −0.35 cm, P = 0.049) and more significant effects were observed in non-menopausal women reduced body weight (−0.59 kg, P = 0.041), BMI (−0.59, P = 0.041) and waist circumference (−0.59 cm, P = 0.041) in overweight or obese populations. Conclusion: This meta-analysis showed that soy products have weight loss effects, mainly due to soy protein, isoflavone and soy fiber.

Highlights

Obesity is a major public health problem facing mankind today
Any study that met the following criteria was included: they (1) were restricted randomized controlled trials to investigate the association between intake of soy products and obesity-related anthropometric indicators; (2) had a target population of overweight or obese people; (3) reported a net change between the means of body weight, body mass index (BMI), body fat percentage, fat mass, fat-free mass, waist circumference, hip circumference or waist–hip ratio (WHR) before and after intervention with their corresponding standard deviations (SD), standard errors (SE), interquartile range (IQR), 95% confidence intervals (CI), or probability values; (4) provided the main ingredients and dosage of soy products
The real effect need to be demonstrated in well-designed, larger randomized controlled trials for overweight or obese subjects. This meta-analysis showed that soy products supplementation could be helpful in reducing body weight, BMI, body fat percentage, fat mass and waist circumference in overweight or obese Asians

Summary

Introduction

Obesity is a major public health problem facing mankind today. The worldwide prevalence of obesity has increased more than doubled between 1980 and 2014 [1]. In the United States alone, obesity-related medical costs have increased by $68.5 billion annually in the last 10 years [4]. The effect of soy products on the weight of overweight or obese people is controversial, so we aimed to conduct a systematic review and a meta-analysis of published randomized controlled trials to analyze whether supplementation with soy products can help them to lose weight. Analysis showed that soy products significantly reduced body weight, BMI, body fat percent and waist circumference in overweight or obese Asian populations (−0.37 kg, P = 0.010; −0.27 kg/m2 , P = 0.042; −0.36%, P = 0.032; −0.35 cm, P = 0.049) and more significant effects were observed in non-menopausal women reduced body weight Conclusion: This meta-analysis showed that soy products have weight loss effects, mainly due to soy protein, isoflavone and soy fiber

Objectives

Methods

Discussion

Conclusion