Soursop leaf (Annona muricata) and it is potential as an anti-cancer

Abstract

Abstract. Lienggonegoro LA, Kharirie. 2020. Soursop leaf (Annona muricata) and it is potential as an anti-cancer. Pros Sem Nas Masy Biodiv Indon 6: 628-632. Soursop (Annona muricata) leaves have long been used as a traditional medicine to overcome many diseases. Its potential as a drug or cancer prevention makes it often used as an object of research. This review contains various studies of soursop leaves in Indonesia and their methods, both from the in-vitro, in-vivo stages and clinical trials on the use of soursop leaves in Indonesia conducted since 2012. From the literature collected, the in-vitro research found that soursop leaf extract has cytotoxic properties against MCF-7 cancer cell lines, HeLa cells, HUH7IT-1 hepatocellular cancer cells but do not respond to PC3 prostate cancer cells. The effectiveness of soursop leaves also depends on the incubation time and extraction method. Ethanol extract is known to show cytotoxicity compared to water extract. In the in-vivo study, soursop leaf research was carried out on mice breast and mouse cancer models for breast, lung and liver cancer-induced DMBA models. From the results of in-vivo research it is known that soursop leaf extract works as an antiproliferation, chemopreventive and triggers apoptosis. Soursop leaves (Annona muricata) have cytotoxic properties against cancer cells in vitro, which may be caused by antioxidant content, including flavonoids and acetogenin so that it has the potential to be developed as an anti-cancer drug.