Abstract
Adenosine triphosphate (ATP 10 −4 M) induced monophasic contractions in preparations of rat urinary bladder strips. These responses were reversibly abolished in calcium (Ca 2+)-free, ethyleneglycol-bis-(β-amino-ethyl ether)-N, N′-tetra-acetic acid (EGTA 0.1 mM)-containing medium, and were partially inhibited by 10 −6 M verapamil (43%) and 10 −6 M diltiazem (32%). However, the inhibition of ATP-stimulated 45Ca uptake by verapamil and diltiazem was more pronounced (109 and 75%, respectively). The results suggest that, in addition to the primary role of extracellular Ca 2+, intracellular Ca 2+ is involved in ATP-induced contractions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
