Abstract
Sources and regulation of nitric oxide synthesis in uterus smooth muscle cells
Highlights
Nitric oxide (NO) is a universal signaling and regulatory molecule in cells
The optimal work of mtNOS in isolated myometrium mitochondria requires the presence of Ca2+, NADPH and L-arginine in the incubation medium
Predictably, its activity is determined by the intensity of exogenous Ca2+ flow to the matrix and significantly depends on the effectiveness of the Ca2+-calmodulin complex formation, which is the main cofactor of the constitutive isoforms
Summary
Nitric oxide (NO) is a universal signaling and regulatory molecule in cells. One of the important nitric oxide biological actions is control of smooth muscle contractile function that is involved in the maintenance of normal functioning of internal organs, in particular, the genitourinary system [1, 2]. Our previous studies demonstrated NO formation in mitochondria of uterine smooth muscle cells using laser confocal microscopy and specific fluorescence probes.
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