Abstract
Experiments performed at 130 days gestation in 11 rhesus monkeys revealed a positive correlation between pituitary prolactin concentrations in maternal plasma, but not fetal plasma, and those in amniotic fluid. Minute amounts of radioactively-labeled prolactin passed between maternal and fetal circulation. Small amounts of labeled hormone also passed from the mother, but not from the fetus, to the amniotic cavity. Fetal plasma prolactin was elevated by fetalinjection of thyrotropin-releasing factor (TRF), but not to an extent comparable to maternal plasma rises seen after the hypothalamic hormone was injected into the mother. Fetal tissues andthe placenta acquired protein-bound radioactivity when l25I-labeled prolactin was injected intothe amniotic fluid, the 125I in the former organ being displaced by incubation with nonlabeled prolactin. It was concluded that the maternal circulation may be a major source of amniotic fluid prolactin, while fetal and maternal circulations show mutually, essentially indep...
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