Abstract
Human saliva contains a substance that inhibits gastric secretion when administered intravenously to dogs or rats. The purpose of this study was to determine which one of the salivary glands elaborates this substance. Individual samples of whole, parotid, submaxillary, and sublingual saliva were collected from normal human subjects. The amount of inhibitory substance in each sample of saliva was estimated by its inhibitory action on the 4-hr, gastric secretion of pylorus-ligated rats. Of the secretions from the 3 principal salivary glands, that from the sublingual glands had the greatest inhibitory effect on gastric secretion of rats. It is proposed that the gastric inhibitory substance present in saliva be called sialogastrone.
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