Abstract
Mass spectrometry (MS) is an important tool for analyzing or detecting a wide range of organic, inorganic, natural, unnatural molecules, especially drugs, proteins, peptides are of interests beside routine analysis..
Highlights
Mass spectrometry (MS) is an important tool for analyzing or detecting a wide range of organic, inorganic, natural, unnatural molecules, especially drugs, proteins, peptides are of interests beside routine analysis [1]
Sourceinduced dissociation (SID) and collision-induced dissociation (CID) fragmentation in electrospray ionization (ESI) Ion-Trap were compared to get the maximum benefit of the qualitative power of Ion-Trap mass spectrometry (ITMS)
More qualitative information was obtained using SID comparing to CID of ESI Ion-Trap for fragmentation of four antiviral drugs acyclovir, abacavir, famciclovir and penciclovir
Summary
Mass spectrometry (MS) is an important tool for analyzing or detecting a wide range of organic, inorganic, natural, unnatural molecules, especially drugs, proteins, peptides are of interests beside routine analysis [1]. Fragmentation pathways of four antiviral drugs (Acyclovir, Abacavir, Famciclovir and Penciclovir) were investigated using two possible fragmentation methods of Ion-Trap mass spectrometry (ITMS). Sourceinduced dissociation (SID) and collision-induced dissociation (CID) fragmentation in ESI Ion-Trap were compared to get the maximum benefit of the qualitative power of ITMS.
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