Source-free collaborative domain adaptation via multi-perspective feature enrichment for functional MRI analysis

Abstract

Resting-state functional MRI (rs-fMRI) is increasingly employed in multi-site research to analyze neurological disorders, but there exists cross-site/domain data heterogeneity caused by site effects such as differences in scanners/protocols. Existing domain adaptation methods that reduce fMRI heterogeneity generally require accessing source domain data, which is challenging due to privacy concerns and/or data storage burdens. To this end, we propose a source-free collaborative domain adaptation (SCDA) framework using only a pretrained source model and unlabeled target data. Specifically, a multi-perspective feature enrichment method (MFE) is developed to dynamically exploit target fMRIs from multiple views. To facilitate efficient source-to-target knowledge transfer without accessing source data, we initialize MFE using parameters of a pretrained source model. We also introduce an unsupervised pretraining strategy using 3,806 unlabeled fMRIs from three large-scale auxiliary databases. Experimental results on three public and one private datasets show the efficacy of our method in cross-scanner and cross-study prediction.