Abstract

This study proposes a new artificial intelligence model based on cardiovascular computed tomography for more efficient and precise recognition of Tetralogy of Fallot (TOF). Our model is a structurally optimized stochastic pooling convolutional neural network (SOSPCNN), which combines stochastic pooling, structural optimization, and convolutional neural network. In addition, multiple-way data augmentation is used to overcome overfitting. Grad-CAM is employed to provide explainability to the proposed SOSPCNN model. Meanwhile, both desktop and web apps are developed based on this SOSPCNN model. The results on ten runs of 10-fold cross-validation show that our SOSPCNN model yields a sensitivity of 92.25±2.19, a specificity of 92.75±2.49, a precision of 92.79±2.29, an accuracy of 92.50±1.18, an F1 score of 92.48±1.17, an MCC of 85.06±2.38, an FMI of 92.50±1.17, and an AUC of 0.9587. The SOSPCNN method performed better than three state-of-the-art TOF recognition approaches.

Highlights

  • Tetralogy of Fallot (TOF) is a congenital defect that influences normal blood flow through the heart [1]

  • The model arrives at a performance with a sensitivity of 92:25 ± 2:19, a specificity of 92:75 ± 2:49, a precision of 92:79 ± 2:29, an Approach morphological classification (MC) [8] 3DCNN [9] ventricular contouring convolutional neural networks (CNNs) (VCCNN) [10] stochastic pooling convolutional neural network (SOSPCNN)

  • This paper proposes a web app for TOF recognition

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Summary

Introduction

Tetralogy of Fallot (TOF) is a congenital defect that influences normal blood flow through the heart [1]. It is made up of 4 defects of the heart and its blood vessels [2]: (a) ventricular septal defect, (b) overriding aorta, (c) right ventricular outflow tract stenosis, and (d) right ventricular hypertrophy. Defects of TOF can cause oxygen in the blood that flows to the rest of the body to be reduced. Infants with TOF have a bluish-looking skin color [3] since their blood does not carry enough oxygen. Traditional diagnosis of TOF is after a baby is born, often after the infant had an episode of cyanosis during crying or feeding. Computed tomography (CT) has shown its success in the differential diagnosis of TOF [5], since it can provide detailed images of many types of cardiovascular issue; besides, computed tomography (CT) can be performed even if the subject has an implanted medical device, unlike magnetic resonance imaging (MRI) [6]

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