Abstract
Sinusoidal obstruction syndrome (SOS), better known as veno-occlusive disease, is a serious and life-threatening complication that mainly occurs after high-dose myeloablative conditioning therapy and haemopoietic stem-cell transplantation (HSCT). The disease can affect about 20% of such patients and is characterised clinically by increased serum bilirubin concentrations, tender hepatomegaly, fluid retention, and weight gain. Liver injury occurs early after transplantation and results in occluded venules, sinusoidal fibrosis, and hepatocyte necrosis.
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