Abstract
a variety ofmodifications before appearing on the cell surface. Here the receptor protein binds circulating low density lipoprotein, a cholesterol carrier, and the two are internalised by surface invaginations called coated pits. These pinch off to form coated vesicles, and uncoating is followed by fusion with endosomes. Low density lipoprotein is parted from the receptor, delivered to lysosomes, and degraded; the cholesterol so released passes to the endoplasmic reticulum, where membrane synthesis takes place. The receptor is recycled from the endosomes back to the cell surface, where it participates in roughly a hundred more rounds of internalisation. It too is then degraded in lysosomes.
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