Abstract
Further studies were carried out on the interaction of monoclonal antibodies (MAbs) with cyanoacrylic nanoparticles (NP). Even after incubation in culture media with seric proteins, these immunoparticles conserved a good immunoreactivity and a sufficient stability for potential usefulness in targeting. On the other hand, optimal conditions were determined for using these NP as a solid phase for immunoassays. More surprisingly, it was observed that radiolabelling of monoclonal antibodies with iodine induced important changes in the physicochemical interaction between the protein and the polymeric support.
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