Sorption of proteins on porous carboxylic cation exchangers

Abstract

1. Protein adsorption on the Ht forms of carboxylic cation exchangers can be described in terms of the electrostatic potential of the exchanger phase, using the equation which we have proposed earlier in which allowance is made for the change of the ionic state of the protein and its isoelectric point. 2. The energy of interaction between protein and exchanger is determined by the dipole moment of the protein and the electrostatic potential of the exchanger phase. 3. Maximum selective desorption of the acidic proteins occurs in the neighborhood of the isoelectric point.