Abstract
This chapter discusses the description, methods of preparation, physical properties, excipient studies, stability, and methods of analysis of sorbitol. Sorbitol is an odorless powder that is white or almost colorless. Various grades based on particle size are available, and it is obtained in various forms such as flakes, granules, pellets, or powder. Sorbitol is a hexahydric alcohol that is isomeric with mannitol. It has been described as a humectant, plasticizer, sweetening agent, and tablet and capsule diluent. It is used extensively in the pharmaceutical, cosmetics, and food industries, because it has a sweet taste and approximately 50–60% the sweetness of sucrose. In pharmaceutical applications, sorbitol is used as a tablet diluent in wet granulation or dry compression formulations. It is commonly used in chewable tablets because of its sweet taste, and it is used as a plasticizer for gelatin in capsule formulations. Sorbitol is utilized in sugar-free liquid preparations and as a stabilizer for drug, vitamin, and antacid suspensions. When it is used in syrups, crystallization around bottle caps is prevented. Sorbitol has also been used in injectable and topical products, and has a therapeutic use as an osmotic laxative.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
