Abstract
The clinical application of sorafenib is limited because of its hydrophobicity, low bioavailability and unsatisfying treatment effect. Therefore, sorafenib-loaded PEG-poly (ε-caprolactone) micelles (SF micelles) were fabricated for sorafenib delivery. Invitro assays investigated the solubility, dispersity, stability, cytotoxicity and uptake capacity of SF micelles. Invivo biodistribution and therapeutic effects were studied using HepG2-Luc tumor-bearing mice. SF micelles had a regular spherical structure with good water solubility. Invivo imaging results showed PEG-poly (ε-caprolactone) micelles could elevate the sorafenib concentration in tumor tissues. Meanwhile, SF micelles exhibited higher tumor growth inhibition invivo. SF micelles might be a potential drug delivery system, which could enhance the therapeutic effects of sorafenib.
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