Abstract
Several studies have consistently demonstrated the capability of ultrasound to enhance the lysis of intra-arterial thrombi in acute ischemic stroke during systemic intravenous thrombolysis with tissue plasimogen activator (tPA), an intervention also called sonothrombolysis. ### Objectives 1. To quantify the potential benefits of sonothrombolysis in acute ischemic stroke. 2. To quantify the potential harms of sonothrombolysis. ### Types of Studies Randomized controlled trials with clear allocation concealment. ### Types of Participants Patients admitted to hospital with acute ischemic stroke. ### Types of Interventions Sonothrombolysis versus intravenous tPA therapy alone or …
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