Abstract
Reperfusion injury is common following primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction. In a prospective Canadian single-arm study of 15patients, the use of myocardial contrast echocardiography with high mechanical index ultrasound impulses (sonothrombolysis) initiated prior to primary PCI resulted in 7 patients with pre-PCI thrombolysis in myocardial infarction-2/3 flow (46.7%). Following reperfusion, all 15 patients had thrombolysis in myocardial infarction-3 flow, and 14 patients achieved ST-segment resolution ≥ 50% at 30 minutes post-PCI (93.3%). At 90 days, 12 patients had normal left ventricular ejection fraction ≥ 50% (80.0%). Our results demonstrate the feasibility of a novel technique to enhance reperfusion in ST-elevation myocardial infarction and provide a rationale for a randomized Canadian study.
Highlights
Reperfusion injury is common following primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction
Prompt reperfusion with primary percutaneous coronary intervention improves clinical outcomes in ST-elevation myocardial infarction (STEMI), abrupt recanalization often leads to reperfusion injury and microvascular dysfunction
In the first North American study, we evaluated the effects of sonothrombolysis on epicardial patency, myocardial perfusion, and left ventricular performance in STEMI
Summary
Reperfusion injury is common following primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction. RESUME La lesion de reperfusion est frequente après l’intervention coronarienne percutanee (ICP) primaire chez les patients atteints d’un infarctus du myocarde avec elevation du segment ST. Dans une etude prospective canadienne, à volet unique, auprès de 15 patients, l’utilisation de l’echocardiographie myocardique de contraste par des impulsions ultrasonores à indice mecanique eleve (sonothrombolyse) amorcee avant l’ICP primaire s’est traduite par sept patients qui ont eu une thrombolyse pre-ICP de l’infarctus du myocarde de flux de grade. Les 15 patients ont subi une thrombolyse de l’infarctus du myocarde de flux de grade 3, et 14 patients ont eu une resolution du segment ST ! In the first North American study, we evaluated the effects of sonothrombolysis on epicardial patency, myocardial perfusion, and left ventricular performance in STEMI
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
