Abstract
In the present study, an attempt has been made to enhance the transdermal permeation of prednisolone acetate through rat abdominal skin from topical hydrogel formulations with the help of sonophoresis and iontophoresis. The topical hydrogels were prepared using sodium alginate and carbopol; further they were evaluated for drug content uniformity, ex-vivo skin permeation with or without sonophoresis/iontophoresis and skin histopathology. Results reveal that under iontophoretic and sonophoretic conditions, the drug permeation was enhanced 2-3 folds as compared to the drug permeation under passive condition (without sonophoresis/iontophoresis). The presence of cineole enhanced the permeation of drug under iontophoretic and sonophoretic conditions to a greater extent. The histopathological evaluation of skin suggests that there were changes in the skin structure after application of ultrasound/DC electric current.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
